St john's wort

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PDR for Herbal Medicines, Fourth Edition Thomson Healthcare, Inc. See book keywords and concepts

Acute neuropathy after exposure to sun in a patient treated with st john's wort. Lancet 352(9134):1121-1122. 1998. Brantner A, Kartnig T, Quehenberger F. Vergleichende phytochemische Untersuchungen an Hypericum perforatum L., und Hypericum maculatum (Crantz). Sci Pharm 62:261-276. 1994. Breidenhach T, Hoffmann MW, Becker T, et al: Drug interaction of St. John's Wort with cyclosporine (letter). Lancet 355(9218): 1912. 2000. Breidenbach T, Kliem V, Burg M, et al: Profound drop of cyclosporin A whole blood trough levels caused by St. John's Wort (Hypericum perforatum).

PDR for Herbal Medicines Joerg Gruenwald, Ph.D. See book keywords and concepts

Linde K et al., st john's wort for depression - An overview and meta-analysis of randomized clinical trials. In: Brit Med J 313(7052):253-258. 1996. Lopez-Bazzocchi I, Hudson JB, Towers GHN, Antiviral activity of the photoactive plant pigment hypericin. In: Photochem Photobiol 54:95-98. 1991. Maisenbacher P, Johanniskrautol. In: DAZ 132(6):281. 1992. Mathic C, Ourrison G, (1964) Phytochemistry 3:115, 133, 377, 379. Miiller WE, Schafer C, Johanniskraut In-vitro-Studie iiber Hypericum-Extrakt, Hypericin und Kampferol. In: DAZ 136(13):1015-1022. 1996.

Handbook of Medicinal Plants Amarjit S. Basra See book keywords and concepts

St John's wort: Prozac from the plant kingdom. Trends in Pharmacological Sciences, 22: 292-297; Barnes, J., Anderson, L.A., and Phillipson, J.D.. 2001, st john's wort (Hypericum perforatum L.): A review of its chemistry, pharmacology and clinical properties, Journal of Pharmacy and Pharmacology, 53: 583-600. 20. Hypericum Depression Trial Study Group, 2002, Effect of Hypericum perforatum (St. John's wort) in major depressive disorder, Journal of the American Medical Association, 287: 1807-1814. 21. Di Carlo et al., 2001, St. John's wort. 22. Palevitch. D.

St John's wort induces intestinal P-glycoprotein/MDRl and intestinal and hepatic CYP3A4, Clinical Pharmacology and Therapeutics, 68: 598-604. 35. Sugimoto, K. et al., 2001, Different effects of st john's wort on the pharmacokinetics of simvastatin and pravastatin, Clinical Pharmacology and Therapeutics, 70: 518-524. 36. Ernst, E., 1997, Complementary AIDS therapies: the good, the bad, and the ugly, Int. J. STDAIDS, 8: 281-285. 37. Piscitelli, S.C., Burstein, A.H., Welden, N., Gallicano, K.D., and Falloon, J., 2002, The effect of garlic supplements on the pharmacokinetics of saquinavir, Clin.

PDR for Herbal Medicines, Fourth Edition Thomson Healthcare, Inc. See book keywords and concepts

Clinical Management: Concurrent use of linezolid and st john's wort may result in serotonin syndrome. Monitor for serotonin syndrome effects including confusion, delirium, restlessness, tremors, blushing, diaphoresis, and hyperpyrexia. Consider a waiting period of 14 days between administration of these drugs. Monoamine Oxidase Inhibitors: Concurrent use may result in an increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) and/or an increased risk of hypertensive crisis. Clinical Management: Avoid concomitant use of St.

DeMott K. st john's wort tied to serotonin syndrome. Clin Psychiatry 26:28. 1998. Denke A, Schempp H, Weiser D, et al: Biochemical activities of extracts from hypericum perforatum L. 5th communication: dopamine- beta-hydroxylase product quantification by HPLC and inhibition by hypericins and flavonoids. Arzneim-Forsch Drug Res 50(5):415-419. 2000. DeSmet PM, Touw DJ. Safety of St. John's Wort (Hypericum perforatum) (letter). Lancet 355(9203):575-576. 2000. DeSmet PA, Nolen W. St. John's Wort as an antidepressant. BMJ 313:241-242. 1996. Dimpfel W, Schober F, Mannel M.

Pilkington K, Boshnakova A, Richardson J. st john's wort for depression: Time for a different perspective? Comp Ther Med; 14: 268-281. 2006. Piscitelli S, Burstein A, Chaitt D; et al: Indinavir concentrations and St. John's Wort. Lancet 355(9203):547-548. 2000. Poginsky B, Westendorf, J, Prosenc N, et al: Johanniskraut (Hypericum perforatum L.) Genotoxizitaet bedingt durch den Puercetingehalt. Dtsch Apoth Ztg 128:(126) 1364-1366. 1988. Product Information: Amerge (naratriptan hydrochloride). Glaxo Wellcome Inc, Research Triangle Park, NC. 1999. Product Information: Cordarone (amiodarone).

St John's wort or sertraline? Can Fam Physician 48:905-912. 2002. Vasilchenko EA. Analgesic action of flavonoids of Rhododendron uteum Sweet, Hypericum perforatum L, Lespedeza bicolor Turcz. ind L. hedysaroides (Pall.) Kitag. Rastit Resur 1986; 22:12-21. 986. Verotta L, Appcndino G, Bclloro E, et al: Furohyperforin, a prenylated phloroglucinol from St. John's wort {Hypericum perforatum). J Nat Prod 62:770-772. 1999. Vitiello B. Hypericum perforatum extracts as potential antidepressants. J Pharm Pharmacol 51(5):5 L3-517. 1999. Volz HP.

St John's Wort before initiating selegiline. MAJOR RISK Amiodarone: Concurrent use may result in reduced amiodar-one levels. Clinical Management: Concurrent use of amiodarone and St. John's Wort is not recommended. Given the extended half-life of amiodarone, potential for drug interaction may exist even after discontinuation of amiodarone. Amsacrine: Concurrent use may result in reduced effectiveness of amsacrine. Clinical Management: Avoid concomitant use of St. John's Wort and amsacrine.

Handbook of Medicinal Plants Amarjit S. Basra See book keywords and concepts

St John's wort (Hypericum perforatum L.): A review of its chemistry, pharmacology and clinical properties, Journal of Pharmacy and Pharmacology, 53: 583-600. 20. Hypericum Depression Trial Study Group, 2002, Effect of Hypericum perforatum (St. John's wort) in major depressive disorder, Journal of the American Medical Association, 287: 1807-1814. 21. Di Carlo et al., 2001, St. John's wort. 22. Palevitch. D., 1997, Feverfew (Tanacetum parthenium) as a prophylactic treatment for migraine: A double-blind, placebo-controlled study, Phytotherapy Research. 11: 508-511; Murphy, J.J.

Fundamentals of Naturopathic Endocrinology Michael Friedman, ND See book keywords and concepts

For instance, Chimaphila umbellata can be used to treat cystitis. st john's wort (Hypericum perforatum) can be prescribed if depression, insomnia, or sciatica are present. Anxiolytic herbs, such as kava kava (Piper methysicum), can be employed if insomnia or anxiety is present. Bio-identical Hormones Bio-indentical Progesterone: Replacing progesterone alone, by application of bio-indentical progesterone cream, can be used as a first line treatment of vasomotor symptoms. Although progesterone by itself is not as effective as estrogen, it can be useful when estrogens are contraindicated.

Anti-Aging Manual: The Encyclopedia of Natural Health Joseph E. Mario See book keywords and concepts

Antidepressant Lavender, st john's wort, Oats, Damiana, Rosemary, and Schizandra. Anti-Emetic Relieves vomiting and nausea: Sheep Sorrel. Includes stimulants, and cerebrospinants. Antifungal Cinnamon, Garlic, Pau D'Arco, Propolis, and Black Walnut. Anti-InflammatoryA* Angelica, BlackHaw, Chaparral, Fenugreek, Gentian, Horsetail, Juniper,Turmeric,Vervain. Devil's Claw, Meadowsweet, Oak bark, Passionflower, Plantain, and White Willow bark. Antileptic Relieves seizures. Antimicrobial Echinacea, Garlic, Wild Indigo, Mullein, Myrrh, and Thyme.

Handbook of Medicinal Plants Amarjit S. Basra See book keywords and concepts

C, Antibacterial activity of hyperforin from st john's wort, against multiresistant Staphylococcus aureus and gram-positive bacteria. Lancet 1999, .353, (9170), 2129. 72. Amaro-Luis. J. M.; Adrian, M.; Diaz, C, Isolation, identification and antimicrobial activity of ombuoside from Stevia triflora. Ann Pharm Fr 1997, 55, (6), 262-268. 73. Mitscher, L. A.; Telikepalli, H., Bioassay-directed discovery of natural product leads. Antibacterials and antifungals from unusual sources. In Advances in natural product chemistry, ed. Atta-ur-Rahman. Harwood Academic Publishers: Basel, 1992, pp. 281-310.

Big Pharma: Exposing the Global Healthcare Agenda Jacky Law See book keywords and concepts

A couple of years ago, for example, a $6 million study found the herbal remedy st john's wort was less effective than a placebo, apparently as a vindication of conventional medicine. While the herb had managed to help only 24% of cases of moderate to severe depression, the placebo scored 32%. It later emerged that Zoloft was also part of the trial and had helped 25%.14 The clinical difference is not that impressive - and it is getting worse.

Handbook of Medicinal Plants Amarjit S. Basra See book keywords and concepts

The pharmacokinetic profile of simvastatin after repeated administration of st john's wort or its placebo in a double-blind, crossover study was reported by Sugimoto et al.35 In this study, St. John's wort significantly decreased plasma simvastatin hydroxy acid. However, the therapeutic manifestation of coadministration of St. John's wort was not determined. St. John's wort may reduce the cholesterol-lowering effect of simvastatin, demonstrating the critical effects that herbal preparations may have on drug pharmacokinetics in the GI tract. Further study is needed to address this issue.

Interview with Dr. Lindsey Duncan, founder of Genesis Today (herbal cleansing / detox supplements) Mike Adams, the Health Ranger See article keywords and concepts

Depression is also not a deficiency of st john's wort. Mike:Exactly. Dr. Duncan: A headache is not a deficiency of Tylenol. It's also not a deficiency of feverfew. Go to the core. Mike: Right. Dr. Duncan: Go to the root. Go deep and you'll get the answer. Mike: And I want to cover a touchy subject that you already mentioned. Some people aren't comfortable even talking about bowel movements, but I say, "Look, let's talk about it." And I've found a great misconception over what people think is normal. People will think once a day is perfectly healthy.

Handbook of Medicinal Plants Amarjit S. Basra See book keywords and concepts

Different effects of st john's wort on the pharmacokinetics of simvastatin and pravastatin, Clinical Pharmacology and Therapeutics, 70: 518-524. 36. Ernst, E., 1997, Complementary AIDS therapies: the good, the bad, and the ugly, Int. J. STDAIDS, 8: 281-285. 37. Piscitelli, S.C., Burstein, A.H., Welden, N., Gallicano, K.D., and Falloon, J., 2002, The effect of garlic supplements on the pharmacokinetics of saquinavir, Clin. Infect. Dis., 34: 234-238. 38.

Fundamentals of Pharmacognosy and Phytotherapy Dr. Michael Heinrich, Joanne Barnes, Simon Gibbons and Elizabeth M. Williamson See book keywords and concepts

One of the most significant series of herb-drug interactions observed in recent years has been that of st john's wort, currently popular for self-treatment of minor depression. Some of these interactions have been so severe as to cause the Committee on Safety of Medicines to issue warnings about the use of this herb with a series of prescription medicines, including the contraceptive pill, digoxin, HIV protease inhibitors, selective serotonin reuptake inhibitors, theophylline and warfarin (Barnes et al 2001).

The Constituents of Medicinal Plants: An Introduction to the Chemistry and Therapeutics of Herbal Medicine Andrew Pengelly See book keywords and concepts

The main anthraquinone-containing plants are cascara sagrada [Rbamnus purshiana), senna, rhubarb, aloes, dock and st john's wort. Rheum-emodin is a typical simple anthraquinone from rhubarb root [Rheum palmatum). oh o oh rheum-emodin As anthraquinones are yellow-brown pigments many have been used historically as dyes for textiles, for example dyer's madder (Rubia tinctoria). They are also known as anthracene glycosides, since anthracene was the first compound isolated, by French chemists Dumas and Lambert, in 1832.

The New Encyclopedia of Vitamins, Minerals, Supplements and Herbs Nicola Reavley See book keywords and concepts

When the results of the trials were put together, they showed that st john's wort extracts were significantly better than placebo. Fifty-five per cent of patients given st john's wort found that their symptoms improved, whereas only 22 per cent of patients in the placebo group showed improvement. Other herbs that can be used to treat depression and strengthen the nervous system include vervain (Verbena officinalis), oat straw (Avena sativa), skullcap (Scutellaria laterifolia) and lemon balm (Melissa officinalis). Kava (Piper methysticum) has been used to treat anxiety.

Fundamentals of Pharmacognosy and Phytotherapy Dr. Michael Heinrich, Joanne Barnes, Simon Gibbons and Elizabeth M. Williamson See book keywords and concepts

For example, st john's wort (Hypericum perforatum L.) is used in both rational phytotherapy and by herbalists. Table 12.

However, since 1996, there has been a significant increase in the publication of randomized clinical trials on herbs, such as echinacea, garlic, ginkgo and st john's wort. Although some of these clinical trials are flawed by methodological weaknesses, there can be no doubt that clinical interest in medicinal herbs is growing. Use of herb extracts or isolated active principles The focus on the isolation of active principles from herbs in the past has led to the view that each individual herb must have an active principle(s).

The Natural Way to Heal: 65 Ways to Create Superior Health Walter Last See book keywords and concepts

Generally try motherwort, dong quai, raspberry shoots, and chasteberry (Vitex agnus-castus); st john's wort for depression; and black cohosh for period pain. Maca is most helpful for all conditions, helps after hysterectomy, is safer than hormonal replacement therapy, and is also recommended for age-related decline of sexual function. additional therapies: Take a hot sitz bath or sit on the north pole of a strong magnet for general strengthening. Press foot reflex areas on heels; use blue lighting to reduce bleeding, orange lighting to increase it.

Fundamentals of Pharmacognosy and Phytotherapy Dr. Michael Heinrich, Joanne Barnes, Simon Gibbons and Elizabeth M. Williamson See book keywords and concepts

A range of actives identified Examples include Echinacea, devil's claw (Harpagophytum procumbens), artichoke (Cynara scolymus), st john's wort (Hypericum perforatum), liquorice (Glycyrrhiza glabra) and many others. Of course, more than one of these situations may apply within a single herb. SOME EXAMPLES OF POLYVALENT ACTION Ginkgo biloba The ginkgolides are known to be platelet-activating factor (RAF) antagonists, which is one of their mechanisms of anti-inflammatory activity, and a synergistic interaction between ginkgolides A and B has been shown.

The ABC Clinical Guide to Herbs Mark Blumenthal See book keywords and concepts

Gaster B, Holroyd J. st john's wort for depression: a systematic review. Arch Intern Med 2000 Jan 24; 160(2): 152-6. General Sale List (GSL). Statutory Instrument 1994 No. 2410; The Medicines (Products Other Than Veterinary Drugs) (General Sale List) Amendment Order 1994. London, U.K.: Her Majesty's Stationery Office (HMSO). 1994. German Homeopathic Pharmacopoeia (GHP), 1st ed. 1978 with supplements through 1991. Translation of the German "Homoopathisches Arzneibuch (HAB 1), Amtliche Ausgabe." Stuttgart, Germany: Deutscher Apotheker Verlag. 1993. GHP. See: German Homeopathic Pharmacopoeia.

Indinavir concentrations and st john's wort. Lancet 2000; 355:547-8. Prost N, Tichadou F, Rodor F, etai. St. John's wort-venlafaxine interaction. PresseMed 2000; 29(23): 1285-6. Raffa R. Screen of receptor and uptake-site activity of hypericin component of St. John's wort reveals sigma receptor binding. Life Sci 1998;62(l6):PL265-70. Reichling J, Weseler A, Sailer R. A current review of the antimicrobial activity of Hypericum perforatum L. Pharmacopsychiatry 2001 ;34 Suppl. 1 :S 116-8. Rezvani A, Overstreet D, Yang Y, et al.

Equivalence of st john's wort extract (Ze 117) and fluoxetine: a randomized, controlled study in mild-moderate depression. Int Clin Psychopharmacol 2000 Mar;15(2):6l-8 Schrader E, Meier B, Brattstrom A. Hypericum treatment of mild-moderate depression in a placebo-controlled study. A prospective, double-blind, randomized, placebo-controlled, multicentre study. Hum Psychopharmacol 1998;13:163-169. Schiile C, Baghai T, Ferrera A, Laackmann G. Neuroendocrine effects of Hypericum perforatum extract WS 5570 in 12 healthy male volunteers. Pharmacopsychiatry 2001;34 Suppl. 1:S 127-133. Schulz V.

Fundamentals of Pharmacognosy and Phytotherapy Dr. Michael Heinrich, Joanne Barnes, Simon Gibbons and Elizabeth M. Williamson See book keywords and concepts

TYPES OF DRUGS DERIVED FROM PLANTS Herbal drugs, derived from specific parts of a medicinal plant These are known as herbal medicinal products (HMPs), herbal remedies or phytomedicines and include, for example: • The herb of st john's wort (Hypericum perforatum), used in the treatment of mild to moderate depression. • The leaves of Ginkgo blloba, used for cognitive deficiencies (often in the elderly), including impairment of memory and affective symptoms such as anxiety.

The ABC Clinical Guide to Herbs Mark Blumenthal See book keywords and concepts

Wentworth JM, Agostini M, Love J, etai st john's wort, a herbal antidepressant, activates the steroid X receptor. J Endocrinol 2000;166:R11-R16. Weiss R, Fintelmann V. Herbal Medicine, 2nd ed. New York: Thieme; 2000; 235. Wheatley D. LI 160, an extract of St.John's wort, versus amitriptyline in mildly to moderately depressed outpatients-a controlled 6 week clinical trial. Pharmacopsychiatry 1997; 30(suppl.):77-80. WHO. See: World Health Organization. Wichtl M (ed.). Teedrogen und Phytopharmaka, 3. Auflage: Ein Handbuch fur die Praxis auf wissenschafilicher Grundlage.

Fundamentals of Pharmacognosy and Phytotherapy Dr. Michael Heinrich, Joanne Barnes, Simon Gibbons and Elizabeth M. Williamson See book keywords and concepts

Hyperici herba, st john's wort). Other extracts These are extracts generally accepted to be pharmacologically active. However, the constituents responsible for this activity are not known and consequently quality markers have to be defined. These give information on the overall quality of the phytomedicine for control purposes and may be used to monitor good manufacturing practice, but cannot be used as evidence that the relevant active compounds are present in sufficient amounts or not. Examples: • Crataegus aerial parts (Crataegi folium cum flore, hawthorn). • Passiflora incarnata L.

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